Assay Detail
Binding
CHEMBL871202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]PDBU from recombinant PKCalpha in presence of phosphatidylserine
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol. 26. Exploring the chemical space surrounding the C1 domain of protein kinase C with DAG-lactones containing aryl groups at the sn-1 and sn-2 positions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 7.54 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL210746 | — | — | 1 | 8.30 |
| CHEMBL209666 | — | — | 1 | 8.15 |
| CHEMBL208618 | — | — | 1 | 8.10 |
| CHEMBL379945 | — | — | 1 | 8.05 |
| CHEMBL110256 | — | — | 1 | 8.05 |
| CHEMBL210666 | — | — | 1 | 8.05 |
| CHEMBL380039 | — | — | 1 | 8.00 |
| CHEMBL378783 | — | — | 1 | 7.92 |
| CHEMBL377577 | — | — | 1 | 7.92 |
| CHEMBL209779 | — | — | 1 | 7.85 |
| CHEMBL209013 | — | — | 1 | 7.85 |
| CHEMBL209140 | — | — | 1 | 7.85 |
| CHEMBL379822 | — | — | 1 | 7.80 |
| CHEMBL210495 | — | — | 1 | 7.80 |
| CHEMBL209830 | — | — | 1 | 7.77 |
| CHEMBL206889 | — | — | 1 | 7.77 |
| CHEMBL377690 | — | — | 1 | 7.75 |
| CHEMBL209938 | — | — | 1 | 7.75 |
| CHEMBL380645 | — | — | 1 | 7.72 |
| CHEMBL209308 | — | — | 1 | 7.66 |
| CHEMBL206786 | — | — | 1 | 7.64 |
| CHEMBL208417 | — | — | 1 | 7.62 |
| CHEMBL210432 | — | — | 1 | 7.57 |
| CHEMBL210725 | — | — | 1 | 7.55 |
| CHEMBL210460 | — | — | 1 | 7.52 |
| CHEMBL210196 | — | — | 1 | 7.44 |
| CHEMBL208568 | — | — | 1 | 7.41 |
| CHEMBL206735 | — | — | 1 | 7.36 |
| CHEMBL109997 | — | — | 1 | 7.35 |
| CHEMBL211049 | — | — | 1 | 7.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL210746 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL209666 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL208618 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL379945 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL110256 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL210666 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL380039 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL378783 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL377577 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL209779 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL209013 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL209140 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL379822 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL210495 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL206889 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL209830 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL209938 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL377690 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL380645 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL209308 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL206786 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL208417 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL210432 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL210725 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL210460 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL210196 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL208568 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL206735 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL109997 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL211049 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL209184 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL209615 | — | Ki | = | 406.0 | nM | 6.39 |
| CHEMBL209616 | — | Ki | = | 670.0 | nM | 6.17 |
| CHEMBL209665 | — | Ki | = | 983.0 | nM | 6.01 |
| CHEMBL210547 | — | Ki | = | 2400.0 | nM | 5.62 |