Compound Detail
CHEMBL110256
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL110256 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MGLVTIFLCJBETJ-HKWRFOASSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
388.5
MW (Da)
4.59
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.32
QED
0
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C alpha type CHEMBL299 | Ki | 8.05 | 7.7233 | 9.0 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C alpha type | Ki | = | 9.0 | nM | 8.05 | Displacement of [20-3H]PDBU from recombinant PKCalpha in presence of phosphatidy... | 16722637 |
| Protein kinase C alpha type | Ki | = | 20.3 | nM | 7.69 | Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from a recombinant protei... | 15163204 |
| Protein kinase C alpha type | Ki | = | 37.0 | nM | 7.43 | Displacement of [20-3H]phorbol-12,13-dibutyrate (PDBu) from a recombinant protei... | 15163204 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15163204 | 10.1021/jm030610k | Protein kinase C alpha type | 2 |
| 15163204 | 10.1021/jm030610k | No relevant target | 1 |
| 16722637 | 10.1021/jm060011o | Protein kinase C alpha type | 1 |
Data from ChEMBL 36 via Core Engine