Assay Detail
Functional
CHEMBL871293
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Antitrypanosomal activity against trypomastigotes of AT1 wild type Trypanosoma brucei brucei 427
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei brucei |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
DNA binding affinity of bisguanidine and bis(2-aminoimidazoline) derivatives with in vivo antitrypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.86 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242759 | — | — | 1 | 8.52 |
| CHEMBL242102 | — | — | 1 | 7.20 |
| CHEMBL9126 | — | — | 1 | - |
| CHEMBL539632 | — | — | 1 | - |
| CHEMBL208821 | — | — | 1 | - |
| CHEMBL1161836 | — | — | 1 | - |
| CHEMBL1161838 | — | — | 1 | - |
| CHEMBL431961 | — | — | 1 | - |
| CHEMBL1161839 | — | — | 1 | - |
| CHEMBL267337 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242759 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL242102 | — | IC50 | = | 63.7 | nM | 7.20 |
| CHEMBL9126 | — | IC50 | - | — | - | |
| CHEMBL539632 | — | IC50 | - | — | - | |
| CHEMBL208821 | — | IC50 | - | — | - | |
| CHEMBL1161836 | — | IC50 | - | — | - | |
| CHEMBL1161838 | — | IC50 | - | — | - | |
| CHEMBL431961 | — | IC50 | - | — | - | |
| CHEMBL1161839 | — | IC50 | - | — | - | |
| CHEMBL267337 | — | IC50 | - | — | - |