Assay Detail
Functional
CHEMBL871309
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D mutant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | FDC-P1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Mast/stem cell growth factor receptor Kit (CHEMBL1936) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.30 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377193 | — | — | 1 | 6.30 |
| CHEMBL207858 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377193 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL207858 | — | IC50 | = | 500.0 | nM | 6.30 |