Compound Detail
CHEMBL207858
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Basic Information
| ChEMBL ID | CHEMBL207858 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QNNCAUNEIPNZAQ-UHFFFAOYSA-N |
4
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
290.3
MW (Da)
3.89
ALogP
2
HBA
3
HBD
68.9
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 7.22 | 7.19 | 60.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 6.34 | 6.34 | 458.0 | 1 |
| Mast/stem cell growth factor receptor Kit CHEMBL1936 | IC50 | 6.3 | 6.3 | 500.0 | 2 |
| Platelet-derived growth factor receptor CHEMBL2096980 | IC50 | 6.02 | 6.02 | 960.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 60.0 | nM | 7.22 | Inhibition of endogenous FLT3 in EOL1 cells | 16722630 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 70.0 | nM | 7.16 | Inhibition of human FLT3 | 16722630 |
| Platelet-derived growth factor receptor beta | IC50 | = | 458.0 | nM | 6.34 | Inhibition of human PDGFR beta | 16722630 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 500.0 | nM | 6.3 | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing wild-type K... | 16722630 |
| Mast/stem cell growth factor receptor Kit | IC50 | = | 500.0 | nM | 6.3 | Inhibition of DNA synthesis in IL3 dependent FDC-P1 cells expressing KIT V558D m... | 16722630 |
| Platelet-derived growth factor receptor | IC50 | = | 960.0 | nM | 6.02 | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | 16722630 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16722630 | 10.1021/jm058033i | Receptor-type tyrosine-protein kinase FLT3 | 3 |
| 16722630 | 10.1021/jm058033i | Mast/stem cell growth factor receptor Kit | 3 |
| 16722630 | 10.1021/jm058033i | Platelet-derived growth factor receptor | 1 |
| 16722630 | 10.1021/jm058033i | Platelet-derived growth factor receptor beta | 1 |
Data from ChEMBL 36 via Core Engine