Assay Detail
Binding
CHEMBL854265
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Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor (CHEMBL2096980) ↗| Type | PROTEIN COMPLEX |
| Organism | Mus musculus |
Publication
Novel bis(1H-indol-2-yl)methanones as potent inhibitors of FLT3 and platelet-derived growth factor receptor tyrosine kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.87 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206915 | — | — | 1 | 6.70 |
| CHEMBL7735 | — | — | 1 | 6.70 |
| CHEMBL7296 | — | — | 1 | 6.52 |
| CHEMBL7602 | — | — | 1 | 6.52 |
| CHEMBL377193 | — | — | 1 | 6.52 |
| CHEMBL378133 | — | — | 1 | 6.40 |
| CHEMBL209084 | — | — | 1 | 6.30 |
| CHEMBL377652 | — | — | 1 | 6.30 |
| CHEMBL380038 | — | — | 1 | 6.29 |
| CHEMBL378558 | — | — | 1 | 6.24 |
| CHEMBL210477 | — | — | 1 | 6.23 |
| CHEMBL209823 | — | — | 1 | 6.21 |
| CHEMBL210355 | — | — | 1 | 6.19 |
| CHEMBL210989 | — | — | 1 | 6.14 |
| CHEMBL209042 | — | — | 1 | 6.12 |
| CHEMBL209774 | — | — | 1 | 6.08 |
| CHEMBL210486 | — | — | 1 | 6.02 |
| CHEMBL207858 | — | — | 1 | 6.02 |
| CHEMBL207483 | — | — | 1 | 6.00 |
| CHEMBL210494 | — | — | 1 | 6.00 |
| CHEMBL208640 | — | — | 1 | 5.92 |
| CHEMBL206894 | — | — | 1 | 5.82 |
| CHEMBL206914 | — | — | 1 | 5.60 |
| CHEMBL377873 | — | — | 1 | 5.55 |
| CHEMBL378930 | — | — | 1 | 5.54 |
| CHEMBL207895 | — | — | 1 | 5.46 |
| CHEMBL209515 | — | — | 1 | 5.39 |
| CHEMBL208909 | — | — | 1 | 5.36 |
| CHEMBL207578 | — | — | 1 | 5.32 |
| CHEMBL7724 | AG1295 | — | 1 | 5.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206915 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7735 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7602 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL377193 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7296 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL378133 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL209084 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL377652 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL380038 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL378558 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL210477 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL209823 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL210355 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL210989 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL209042 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL209774 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL210486 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL207858 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL207483 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL210494 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL208640 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL206894 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL206914 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL377873 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL378930 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL207895 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL209515 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL208909 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL207578 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL7724 | AG1295 | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL206469 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL210726 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL210368 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL206099 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL210425 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL210420 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL207008 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL208712 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL210956 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL383276 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL381997 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL209233 | — | IC50 | > | 30000.0 | nM | - |