Compound Detail
CHEMBL378930
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Basic Information
| ChEMBL ID | CHEMBL378930 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GVYNYFKEQPWOCQ-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
306.3
MW (Da)
3.59
ALogP
3
HBA
3
HBD
78.1
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet-derived growth factor receptor CHEMBL2096980 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 5.18 | 5.18 | 6600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet-derived growth factor receptor | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | 16722630 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 6600.0 | nM | 5.18 | Inhibition of endogenous FLT3 in EOL1 cells | 16722630 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16722630 | 10.1021/jm058033i | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 16722630 | 10.1021/jm058033i | Platelet-derived growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine