Compound Detail
CHEMBL210420
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Basic Information
| ChEMBL ID | CHEMBL210420 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QAKBRLMMNDWGCC-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
401.5
MW (Da)
5.05
ALogP
3
HBA
2
HBD
61.1
PSA (Ų)
0.44
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 CHEMBL1974 | IC50 | 6.66 | 6.41 | 220.0 | 2 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Platelet-derived growth factor receptor CHEMBL2096980 | IC50 | 5.0 | 5.0 | 10000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 220.0 | nM | 6.66 | Inhibition of human FLT3 | 16722630 |
| Receptor-type tyrosine-protein kinase FLT3 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of endogenous FLT3 in EOL1 cells | 16722630 |
| Platelet-derived growth factor receptor beta | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of human PDGFR beta | 16722630 |
| Platelet-derived growth factor receptor | IC50 | = | 10000.0 | nM | 5.0 | Inhibition of endogenous PDGFR in Swiss3T3 fibroblasts | 16722630 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16722630 | 10.1021/jm058033i | Receptor-type tyrosine-protein kinase FLT3 | 2 |
| 16722630 | 10.1021/jm058033i | Platelet-derived growth factor receptor | 1 |
| 16722630 | 10.1021/jm058033i | Platelet-derived growth factor receptor beta | 1 |
Data from ChEMBL 36 via Core Engine