Assay Detail
Functional
CHEMBL871425
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Activity at rat 5HT2A receptor assessed as 5-HT-stimulated IP3 accumulation
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
C-(4,5,6-trimethoxyindan-1-yl)methanamine: a mescaline analogue designed using a homology model of the 5-HT2A receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 5 | - | - |
| EC50 | 5 | 5.92 | 8.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 2 | 8.01 |
| CHEMBL379780 | — | — | 2 | 5.50 |
| CHEMBL211309 | — | — | 2 | 5.21 |
| CHEMBL26687 | MESCALINE | 1.0 | 2 | 4.95 |
| CHEMBL211301 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | EC50 | = | 9.8 | nM | 8.01 |
| CHEMBL379780 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL211309 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL26687 | MESCALINE | EC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL263881 | LYSERGIDE | Activity | = | 20.0 | % | - |
| CHEMBL211301 | — | Activity | = | 59.0 | % | - |
| CHEMBL211301 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL379780 | — | Activity | = | 88.0 | % | - |
| CHEMBL211309 | — | Activity | = | 83.0 | % | - |
| CHEMBL26687 | MESCALINE | Activity | = | 86.0 | % | - |