Assay Detail
Functional
CHEMBL871948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for growth inhibition against HL-60(human promyelocytic leukemia) cell line in the presence of UVA(ultra violet A irradiated)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
New tetracyclic analogues of photochemotherapeutic drugs 5-MOP and 8-MOP: synthesis, DNA interaction, and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.54 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342425 | — | — | 1 | 6.22 |
| CHEMBL345062 | — | — | 1 | 6.14 |
| CHEMBL138845 | — | — | 1 | 5.47 |
| CHEMBL136386 | — | — | 1 | 5.46 |
| CHEMBL138512 | — | — | 1 | 5.35 |
| CHEMBL138861 | — | — | 1 | 5.31 |
| CHEMBL345061 | — | — | 1 | 5.19 |
| CHEMBL341689 | — | — | 1 | 5.14 |
| CHEMBL336233 | — | — | 1 | - |
| CHEMBL138134 | — | — | 1 | - |
| CHEMBL136473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342425 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL345062 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL138845 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL136386 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL138512 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL138861 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL345061 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL341689 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL336233 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL138134 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL136473 | — | IC50 | > | 20000.0 | nM | - |