Assay Detail
Binding
CHEMBL872393
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant for I-125-IMPY binding to amyloid plaques in Alzheimers disease brain homogenates
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
F-18 stilbenes as PET imaging agents for detecting beta-amyloid plaques in the brain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.79 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198598 | — | — | 1 | 8.96 |
| CHEMBL381642 | — | — | 1 | 8.92 |
| CHEMBL1788111 | — | — | 1 | 8.55 |
| CHEMBL567747 | — | — | 1 | 8.30 |
| CHEMBL198597 | — | — | 1 | 7.82 |
| CHEMBL1169460 | — | — | 1 | 7.82 |
| CHEMBL196941 | — | — | 1 | 7.49 |
| CHEMBL196407 | — | — | 1 | 7.42 |
| CHEMBL371066 | — | — | 1 | 7.23 |
| CHEMBL196387 | — | — | 1 | 7.10 |
| CHEMBL194754 | — | — | 1 | 7.02 |
| CHEMBL196213 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198598 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL381642 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL1788111 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL567747 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL198597 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1169460 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL196941 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL196407 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL371066 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL196387 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL194754 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL196213 | — | Ki | = | 150.0 | nM | 6.82 |