Compound Detail
CHEMBL567747
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL567747 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MIAAEZHCLGEOTC-XUZJFQRFSA-N |
| Parent Compound | CHEMBL373236 |
| Active Moiety | CHEMBL373236 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
3.86
ALogP
3
HBA
2
HBD
41.5
PSA (Ų)
0.73
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 8.3 | 8.3 | 5.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 5.0 | nM | 8.3 | Inhibition constant for I-125-IMPY binding to amyloid plaques in Alzheimers dise... | 16162001 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16162001 | 10.1021/jm050166g | ADMET | 40 |
| 19845387 | 10.1021/jm901039z | Brain | 2 |
| 16162001 | 10.1021/jm050166g | Amyloid-beta precursor protein | 1 |
| 19845387 | 10.1021/jm901039z | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine