Assay Detail

CHEMBL872633

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Functional

Inhibitory activity against T47D cell line using MTT assay (ER+,mutant p53)

ChEMBL ↗

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Target

T47D (CHEMBL614361) ↗

Open DB target context

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Primary target T47D

CHEMBL614361

Anchored from Assay target.

Protein identity T47D

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	T47D
Confidence	1 — Organism
Curated By	Intermediate

Target

T47D (CHEMBL614361) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.

Stanslas J, Hagan DJ, Ellis MJ, Turner C, Carmichael J, Ward W, Hammonds TR, Stevens MF.
J Med Chem (2000) 43 : 1563 -1572
PubMed 10780913 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	5.68	5.68

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL41174	—	—	1	5.68

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL41174	—	IC50	=	2100.0	nM	5.68