Assay Detail
Binding
CHEMBL872699
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Binding affinity for serotonin transporter was determined in rat cortical membrane.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
N-hydroxyalkyl derivatives of 3 beta-phenyltropane and 1-methylspiro[1H-indoline-3,4'-piperidine]: vesamicol analogues with affinity for monoamine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.51 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127365 | — | — | 1 | 7.57 |
| CHEMBL339281 | — | — | 1 | 7.52 |
| CHEMBL340816 | — | — | 1 | 7.05 |
| CHEMBL126762 | — | — | 1 | 5.35 |
| CHEMBL127790 | — | — | 1 | 5.04 |
| CHEMBL127180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127365 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL339281 | — | Ki | = | 30.05 | nM | 7.52 |
| CHEMBL340816 | — | Ki | = | 88.55 | nM | 7.05 |
| CHEMBL126762 | — | Ki | = | 4434.0 | nM | 5.35 |
| CHEMBL127790 | — | Ki | = | 9201.0 | nM | 5.04 |
| CHEMBL127180 | — | Ki | - | nM | - |