Assay Detail
Functional
CHEMBL872799
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Inhibitory activity against ZR-75-1 cell line using MTT assay (ER+,pgr+,mutant p53)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ZR-75-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.54 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.05 |
| CHEMBL41701 | — | — | 1 | 7.52 |
| CHEMBL41700 | — | — | 1 | 7.52 |
| CHEMBL43453 | — | — | 1 | 6.77 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.75 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.62 |
| CHEMBL38451 | — | — | 1 | 6.41 |
| CHEMBL43229 | — | — | 1 | 6.14 |
| CHEMBL41526 | — | — | 1 | 6.07 |
| CHEMBL41174 | — | — | 1 | 5.81 |
| CHEMBL291263 | — | — | 1 | 5.57 |
| CHEMBL41863 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL41701 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL41700 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL43453 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL43 | AMSACRINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL38451 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL43229 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL41526 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL41174 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL291263 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL41863 | — | IC50 | = | 5590.0 | nM | 5.25 |