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Assay Detail

CHEMBL872896

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]spiperone from dopamine receptor D2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

(S)- and (R)-8-(di-n-propylamino)-6,7,8,9-tetrahydro-3H-benz[e]indole-1- carbaldehyde: a new class of orally active 5-HT1A-receptor agonists.
Stjernlöf P, Gullme M, Elebring T, Andersson B, Wikström H, Lagerquist S, Svensson K, Ekman A, Carlsson A, Sundell S.
J Med Chem (1993) 36 : 2059 -2065
PubMed 8340910 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 6.33 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302172 1 7.00
CHEMBL304426 1 6.92
CHEMBL302171 1 6.84
CHEMBL65196 1 6.81
CHEMBL303339 1 6.77
CHEMBL413105 1 6.52
CHEMBL305341 1 6.46
CHEMBL65274 1 6.42
CHEMBL26998 1 6.08
CHEMBL56 8-OH-DPAT 1 5.87
CHEMBL292274 1 5.80
CHEMBL63449 1 5.45
CHEMBL41436 1 5.29

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302172 Ki = 100.0 nM 7.00
CHEMBL304426 Ki = 120.0 nM 6.92
CHEMBL302171 Ki = 146.0 nM 6.84
CHEMBL65196 Ki = 156.0 nM 6.81
CHEMBL303339 Ki = 170.0 nM 6.77
CHEMBL413105 Ki = 300.0 nM 6.52
CHEMBL305341 Ki = 350.0 nM 6.46
CHEMBL65274 Ki = 382.0 nM 6.42
CHEMBL26998 Ki = 826.0 nM 6.08
CHEMBL56 8-OH-DPAT Ki = 1357.0 nM 5.87
CHEMBL292274 Ki = 1580.0 nM 5.80
CHEMBL63449 Ki = 3592.0 nM 5.45
CHEMBL41436 Ki = 5072.0 nM 5.29