Assay Detail
Binding
CHEMBL872922
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Binding affinity towards 5-hydroxytryptamine 2A receptor using [125I]DOI as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Lysergamides of isomeric 2,4-dimethylazetidines map the binding orientation of the diethylamide moiety in the potent hallucinogenic agent N,N-diethyllysergamide (LSD).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.07 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.46 |
| CHEMBL343755 | — | — | 1 | 8.08 |
| CHEMBL138989 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL343755 | — | Ki | = | 8.3 | nM | 8.08 |
| CHEMBL138989 | — | Ki | = | 21.0 | nM | 7.68 |