Assay Detail
Functional
CHEMBL873001
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Cytotoxicity against human SCLC cells resistant to cisplatin (SCLC/CDDP)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SCLC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design of antineoplastic agents on the basis of the "2-phenylnaphthalene-type" structural pattern. 2. Synthesis and biological activity studies of benzo]b]naphtho[2,3-d]furan-6,11-dione derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.30 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.52 |
| CHEMBL545535 | — | — | 1 | 6.32 |
| CHEMBL542725 | — | — | 1 | 6.23 |
| CHEMBL544602 | — | — | 1 | 6.21 |
| CHEMBL544133 | — | — | 1 | 6.17 |
| CHEMBL541587 | — | — | 1 | 6.03 |
| CHEMBL544361 | — | — | 1 | 5.95 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.89 |
| CHEMBL130408 | — | — | 1 | 5.89 |
| CHEMBL130556 | — | — | 1 | 5.71 |
| CHEMBL555934 | — | — | 1 | 5.59 |
| CHEMBL545305 | — | — | 1 | 5.58 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.17 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.08 |
| CHEMBL132876 | — | — | 1 | - |
| CHEMBL552937 | — | — | 1 | - |
| CHEMBL132737 | — | — | 1 | - |
| CHEMBL131901 | — | — | 1 | - |
| CHEMBL133152 | — | — | 1 | - |
| CHEMBL133347 | — | — | 1 | - |
| CHEMBL130687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL545535 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL542725 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL544602 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL544133 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL541587 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL544361 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL130408 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL130556 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL555934 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL545305 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL132876 | — | IC50 | > | 40300.0 | nM | - |
| CHEMBL552937 | — | IC50 | > | 2600.0 | nM | - |
| CHEMBL132737 | — | IC50 | > | 3400.0 | nM | - |
| CHEMBL131901 | — | IC50 | > | 3500.0 | nM | - |
| CHEMBL133152 | — | IC50 | > | 3200.0 | nM | - |
| CHEMBL133347 | — | IC50 | > | 2500.0 | nM | - |
| CHEMBL130687 | — | IC50 | > | 3800.0 | nM | - |