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Assay Detail

CHEMBL873076

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Resistance factor (IC50 in the resistant cell line/IC50 in the parent cell line)
ChEMBL ↗
44
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Intermediate

Target

Homo sapiens (CHEMBL372) ↗
Type ORGANISM
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.
Pors K, Paniwnyk Z, Ruparelia KC, Teesdale-Spittle PH, Hartley JA, Kelland LR, Patterson LH.
J Med Chem (2004) 47 : 1856 -1859
PubMed 15027879 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 44 5.81 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL52364 — — 2 6.10
CHEMBL418094 — — 2 6.10
CHEMBL55016 — — 2 6.05
CHEMBL51757 — — 2 6.00
CHEMBL54868 — — 2 6.00
CHEMBL55845 — — 2 6.00
CHEMBL53164 — — 2 6.00
CHEMBL53843 — — 2 6.00
CHEMBL296381 — — 2 6.00
CHEMBL55820 — — 2 6.00
CHEMBL52667 — — 2 5.96
CHEMBL51751 — — 2 5.92
CHEMBL55064 — — 2 5.92
CHEMBL55955 — — 2 5.92
CHEMBL53117 — — 2 5.89
CHEMBL417917 — — 2 5.85
CHEMBL57109 — — 2 5.85
CHEMBL51686 — — 2 5.80
CHEMBL293516 — — 2 5.77
CHEMBL300531 — — 2 5.72
CHEMBL515 CHLORAMBUCIL 4.0 2 5.62
CHEMBL11359 CISPLATIN 4.0 2 5.19

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL52364 — IC50 = 800.0 nM 6.10
CHEMBL418094 — IC50 = 800.0 nM 6.10
CHEMBL55016 — IC50 = 900.0 nM 6.05
CHEMBL51757 — IC50 = 1000.0 nM 6.00
CHEMBL55820 — IC50 = 1000.0 nM 6.00
CHEMBL55845 — IC50 = 1000.0 nM 6.00
CHEMBL54868 — IC50 = 1000.0 nM 6.00
CHEMBL53843 — IC50 = 1000.0 nM 6.00
CHEMBL55016 — IC50 = 1000.0 nM 6.00
CHEMBL53164 — IC50 = 1000.0 nM 6.00
CHEMBL296381 — IC50 = 1000.0 nM 6.00
CHEMBL51757 — IC50 = 1100.0 nM 5.96
CHEMBL52667 — IC50 = 1100.0 nM 5.96
CHEMBL54868 — IC50 = 1100.0 nM 5.96
CHEMBL418094 — IC50 = 1100.0 nM 5.96
CHEMBL296381 — IC50 = 1200.0 nM 5.92
CHEMBL52364 — IC50 = 1200.0 nM 5.92
CHEMBL55820 — IC50 = 1200.0 nM 5.92
CHEMBL55064 — IC50 = 1200.0 nM 5.92
CHEMBL55955 — IC50 = 1200.0 nM 5.92
CHEMBL51751 — IC50 = 1200.0 nM 5.92
CHEMBL52667 — IC50 = 1300.0 nM 5.89
CHEMBL53117 — IC50 = 1300.0 nM 5.89
CHEMBL55955 — IC50 = 1400.0 nM 5.85
CHEMBL417917 — IC50 = 1400.0 nM 5.85
CHEMBL57109 — IC50 = 1400.0 nM 5.85
CHEMBL57109 — IC50 = 1400.0 nM 5.85
CHEMBL53164 — IC50 = 1600.0 nM 5.80
CHEMBL51686 — IC50 = 1600.0 nM 5.80
CHEMBL293516 — IC50 = 1700.0 nM 5.77
CHEMBL51751 — IC50 = 1700.0 nM 5.77
CHEMBL55064 — IC50 = 1900.0 nM 5.72
CHEMBL300531 — IC50 = 1900.0 nM 5.72
CHEMBL55845 — IC50 = 1900.0 nM 5.72
CHEMBL417917 — IC50 = 2000.0 nM 5.70
CHEMBL515 CHLORAMBUCIL IC50 = 2400.0 nM 5.62
CHEMBL53117 — IC50 = 2600.0 nM 5.58
CHEMBL53843 — IC50 = 2600.0 nM 5.58
CHEMBL300531 — IC50 = 2700.0 nM 5.57
CHEMBL51686 — IC50 = 2900.0 nM 5.54
CHEMBL293516 — IC50 = 3700.0 nM 5.43
CHEMBL515 CHLORAMBUCIL IC50 = 5800.0 nM 5.24
CHEMBL11359 CISPLATIN IC50 = 6500.0 nM 5.19
CHEMBL11359 CISPLATIN IC50 = 11000.0 nM 4.96