Assay Detail
Binding
CHEMBL873243
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity towards Serotonin transporter was determined by the ability to inhibit [3H]5-HT uptake in rat synaptosomes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL313) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.82 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | — | 1 | 7.13 |
| CHEMBL6842 | — | — | 1 | 7.09 |
| CHEMBL6368 | p-IODOAMPHETAMINE | — | 1 | 7.09 |
| CHEMBL6391 | — | — | 1 | 7.03 |
| CHEMBL6330 | — | — | 1 | 6.97 |
| CHEMBL6731 | TENAMFETAMINE | 2.0 | 1 | 6.32 |
| CHEMBL6376 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6467 | 4-METHYLTHIOAMPHETAMINE | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL6842 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL6368 | p-IODOAMPHETAMINE | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL6391 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL6330 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL6731 | TENAMFETAMINE | IC50 | = | 478.0 | nM | 6.32 |
| CHEMBL6376 | — | IC50 | = | 783.0 | nM | 6.11 |