Assay Detail
Functional
CHEMBL873265
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Concentration required to inhibit production of PGE-2 from THP-1 cells stimulated with A-23187
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | THP-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Pyrrolidine inhibitors of human cytosolic phospholipase A2. Part 2: synthesis of potent and crystallized 4-triphenylmethylthio derivative 'pyrrophenone'.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.19 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.44 |
| CHEMBL15594 | ARACHIDONIC ACID | -1.0 | 1 | 6.75 |
| CHEMBL268905 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL15594 | ARACHIDONIC ACID | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL268905 | — | IC50 | = | 410.0 | nM | 6.39 |