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Assay Detail

CHEMBL873414

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Binding
Binding affinity of compound towards prostaglandin G/H synthase 1 was evaluated
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Ovis aries
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Prostaglandin G/H synthase 1 (CHEMBL2949)
Type SINGLE PROTEIN
Organism Ovis aries

Publication

Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.
Gupta K, Kaub CJ, Carey KN, Casillas EG, Selinsky BS, Loll PJ.
Bioorg Med Chem Lett (2004) 14 : 667 -671
PubMed 14741265 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 2 6.45 6.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL317434 1 6.89
CHEMBL563 FLURBIPROFEN 4.0 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL317434 Ki = 130.0 nM 6.89
CHEMBL563 FLURBIPROFEN Ki = 1000.0 nM 6.00