Assay Detail
Binding
CHEMBL873448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for rat cortical membrane N-methyl-D-aspartate glutamate receptor determined using [3H]CPP as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.17 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90564 | MIDAFOTEL | 2.0 | 1 | 7.40 |
| CHEMBL28862 | — | — | 1 | 6.54 |
| CHEMBL421402 | — | — | 1 | 6.31 |
| CHEMBL84612 | — | — | 1 | 6.06 |
| CHEMBL71898 | — | — | 1 | 4.54 |
| CHEMBL322887 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90564 | MIDAFOTEL | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL28862 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL421402 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL84612 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL71898 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL322887 | — | IC50 | > | 100000.0 | nM | - |