Compound Detail
CHEMBL90564
MIDAFOTEL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL90564 |
| Name | MIDAFOTEL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | VZXMZMJSGLFKQI-ABVWVHJUSA-N |
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
8
Publications
3
Known Names
Molecular Properties
250.2
MW (Da)
-0.96
ALogP
4
HBA
4
HBD
110.1
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Activity Summary
EC50 4 meas. best 6.96
IC50 1 meas. best 7.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Unchecked CHEMBL612545 | EC50 | 6.96 | 6.3475 | 110.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | IC50 | = | 40.0 | nM | 7.4 | In vitro binding affinity for rat cortical membrane N-methyl-D-aspartate glutama... | 12825948 |
| Unchecked | EC50 | = | 110.0 | nM | 6.96 | Effective concentration against NR1/NR2A receptor | 10893301 |
| Unchecked | EC50 | = | 140.0 | nM | 6.85 | Effective concentration against NR1/NR2B receptor | 10893301 |
| Unchecked | EC50 | = | 1460.0 | nM | 5.84 | Effective concentration against NR1/NR2C receptor | 10893301 |
| Unchecked | EC50 | = | 1840.0 | nM | 5.74 | Effective concentration against NR1/NR2D receptor | 10893301 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12825948 | 10.1021/jm0308085 | Mus musculus | 8 |
| 10893301 | 10.1021/jm000007r | Unchecked | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.1016/S0960-894X(00)80087-6 | Rattus norvegicus | 1 |
| 12825948 | 10.1021/jm0308085 | Glutamate NMDA receptor | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine