Assay Detail
Functional
CHEMBL873468
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Predicted pIC50 against Trypomastigotes Brucei rhodesiense.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Activity of bisphosphonates against Trypanosoma brucei rhodesiense.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.97 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434024 | — | — | 1 | 6.66 |
| CHEMBL55557 | — | — | 1 | 6.21 |
| CHEMBL55140 | — | — | 1 | 6.15 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 6.02 |
| CHEMBL293522 | — | — | 1 | 5.77 |
| CHEMBL55812 | OLPADRONIC ACID | 2.0 | 1 | 5.27 |
| CHEMBL55358 | — | — | 1 | 5.11 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 5.07 |
| CHEMBL301247 | — | — | 1 | 5.07 |
| CHEMBL55359 | — | — | 1 | 4.70 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.68 |
| CHEMBL56556 | — | — | 1 | 4.67 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.46 |
| CHEMBL100483 | — | — | 1 | 4.40 |
| CHEMBL417932 | — | — | 1 | 4.40 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.30 |
| CHEMBL54714 | — | — | 1 | 4.27 |
| CHEMBL299988 | — | — | 1 | 4.20 |
| CHEMBL52761 | — | — | 1 | 4.04 |
| CHEMBL299491 | — | — | 1 | 4.00 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434024 | — | IC50 | = | 218.78 | nM | 6.66 |
| CHEMBL55557 | — | IC50 | = | 616.6 | nM | 6.21 |
| CHEMBL55140 | — | IC50 | = | 707.95 | nM | 6.15 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 954.99 | nM | 6.02 |
| CHEMBL293522 | — | IC50 | = | 1698.24 | nM | 5.77 |
| CHEMBL55812 | OLPADRONIC ACID | IC50 | = | 5370.32 | nM | 5.27 |
| CHEMBL55358 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL301247 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL55359 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL56253 | (CYCLOHEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 20892.96 | nM | 4.68 |
| CHEMBL56556 | — | IC50 | = | 21379.62 | nM | 4.67 |
| CHEMBL54344 | (DIETHYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 34673.69 | nM | 4.46 |
| CHEMBL100483 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL417932 | — | IC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL56255 | (PENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL54714 | — | IC50 | = | 53703.18 | nM | 4.27 |
| CHEMBL299988 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL52761 | — | IC50 | = | 91201.08 | nM | 4.04 |
| CHEMBL299491 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55856 | (ISOPENTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 102329.3 | nM | - |