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Assay Detail

CHEMBL873474

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Binding
Binding affinity against sigma receptor
ChEMBL ↗
41
Total Activities
30
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Sigma non-opioid intracellular receptor 1 (CHEMBL3602) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Quantitative structure-activity relationships and eudismic analyses of the presynaptic dopaminergic activity and dopamine D2 and sigma receptor affinities of 3-(3-hydroxyphenyl)piperidines and octahydrobenzo[f]quinolines.
Van de Waterbeemd H, el Tayar N, Testa B, Wikström H, Largent B.
J Med Chem (1987) 30 : 2175 -2181
PubMed 2824774 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 6.83 8.30
Log IC50 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL302721 — — 1 8.30
CHEMBL302556 — — 1 8.30
CHEMBL68855 — — 1 8.10
CHEMBL45778 — — 1 8.05
CHEMBL302071 — — 2 8.00
CHEMBL304388 — — 2 8.00
CHEMBL68960 — — 1 7.85
CHEMBL66208 — — 1 7.80
CHEMBL67221 — — 4 7.72
CHEMBL71776 — — 1 7.64
CHEMBL69766 — — 1 7.57
CHEMBL7393 — — 1 7.52
CHEMBL48219 — — 1 7.51
CHEMBL70193 — — 4 7.32
CHEMBL431168 — — 1 7.19
CHEMBL47750 — — 1 6.95
CHEMBL7549 PRECLAMOL 2.0 1 6.81
CHEMBL424223 — — 1 6.68
CHEMBL71777 — — 1 6.63
CHEMBL432125 — — 1 6.61
CHEMBL49617 — — 1 6.43
CHEMBL309099 — — 1 6.21
CHEMBL49597 — — 1 5.99
CHEMBL46256 — — 1 5.72
CHEMBL1160355 — — 2 5.71
CHEMBL304595 — — 1 5.71
CHEMBL1160354 — — 3 5.63
CHEMBL8268 — — 1 5.34
CHEMBL8033 — — 1 4.81
CHEMBL69826 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL302556 — IC50 = 5.012 nM 8.30
CHEMBL302721 — IC50 = 5.012 nM 8.30
CHEMBL68855 — IC50 = 7.943 nM 8.10
CHEMBL45778 — IC50 = 8.913 nM 8.05
CHEMBL302071 — IC50 = 10.0 nM 8.00
CHEMBL304388 — IC50 = 10.0 nM 8.00
CHEMBL68960 — IC50 = 14.13 nM 7.85
CHEMBL66208 — IC50 = 15.85 nM 7.80
CHEMBL67221 — IC50 = 19.05 nM 7.72
CHEMBL67221 — IC50 = 20.89 nM 7.68
CHEMBL71776 — IC50 = 22.91 nM 7.64
CHEMBL69766 — IC50 = 26.92 nM 7.57
CHEMBL7393 — IC50 = 30.2 nM 7.52
CHEMBL48219 — IC50 = 30.9 nM 7.51
CHEMBL302071 — IC50 = 34.67 nM 7.46
CHEMBL304388 — IC50 = 39.81 nM 7.40
CHEMBL70193 — IC50 = 47.86 nM 7.32
CHEMBL431168 — IC50 = 64.57 nM 7.19
CHEMBL67221 — IC50 = 66.07 nM 7.18
CHEMBL47750 — IC50 = 112.2 nM 6.95
CHEMBL7549 PRECLAMOL IC50 = 154.88 nM 6.81
CHEMBL70193 — IC50 = 194.98 nM 6.71
CHEMBL424223 — IC50 = 208.93 nM 6.68
CHEMBL71777 — IC50 = 234.42 nM 6.63
CHEMBL432125 — IC50 = 245.47 nM 6.61
CHEMBL49617 — IC50 = 371.54 nM 6.43
CHEMBL70193 — IC50 = 416.87 nM 6.38
CHEMBL67221 — IC50 = 524.81 nM 6.28
CHEMBL309099 — IC50 = 616.6 nM 6.21
CHEMBL49597 — IC50 = 1023.29 nM 5.99
CHEMBL46256 — IC50 = 1905.46 nM 5.72
CHEMBL1160355 — IC50 = 1949.84 nM 5.71
CHEMBL304595 — IC50 = 1949.84 nM 5.71
CHEMBL1160354 — IC50 = 2344.23 nM 5.63
CHEMBL1160354 — IC50 = 3630.78 nM 5.44
CHEMBL8268 — IC50 = 4570.88 nM 5.34
CHEMBL1160355 — IC50 = 11481.54 nM 4.94
CHEMBL1160354 — IC50 = 14791.08 nM 4.83
CHEMBL8033 — IC50 = 15488.17 nM 4.81
CHEMBL70193 — Log IC50 = 0.36 uM -
CHEMBL69826 — IC50 = 10964781.96 nM -