Assay Detail
Functional
CHEMBL873502
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Inhibitory concentration against growth of Trypanosoma cruzi amastigotes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 1-amino-1,1-bisphosphonates derived from fatty acids against Trypanosoma cruzi targeting farnesyl pyrophosphate synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.35 | 4.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39581 | — | — | 1 | 4.80 |
| CHEMBL372556 | — | — | 1 | 4.14 |
| CHEMBL198510 | — | — | 1 | 4.11 |
| CHEMBL371748 | — | — | 1 | - |
| CHEMBL196578 | — | — | 1 | - |
| CHEMBL194557 | — | — | 1 | - |
| CHEMBL194624 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39581 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL372556 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL198510 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL371748 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL196578 | — | IC50 | > | 85000.0 | nM | - |
| CHEMBL194557 | — | IC50 | > | 85000.0 | nM | - |
| CHEMBL194624 | — | IC50 | > | 85000.0 | nM | - |