Assay Detail
Binding
CHEMBL873595
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Inhibition of epidermal growth factor receptor (EGFR)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Arylamides of hydroxylated isoquinolines as protein-tyrosine kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49350 | — | — | 1 | 5.85 |
| CHEMBL48436 | — | — | 1 | 5.85 |
| CHEMBL296582 | — | — | 1 | 5.51 |
| CHEMBL50415 | — | — | 1 | 5.25 |
| CHEMBL48650 | — | — | 1 | 5.11 |
| CHEMBL296407 | — | — | 1 | 4.70 |
| CHEMBL48384 | — | — | 1 | - |
| CHEMBL295939 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49350 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL48436 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL296582 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL50415 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL48650 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL296407 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL48384 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295939 | — | IC50 | > | 100000.0 | nM | - |