Assay Detail
Functional
CHEMBL873624
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Antiproliferative activity against P388 Murine Leukemia cells
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | P388 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.87 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138757 | — | — | 1 | 7.00 |
| CHEMBL138203 | — | — | 1 | 6.52 |
| CHEMBL137842 | — | — | 1 | 6.52 |
| CHEMBL370100 | REBECCAMYCIN | — | 1 | 6.52 |
| CHEMBL127277 | — | — | 1 | 6.52 |
| CHEMBL137907 | — | — | 1 | 6.52 |
| CHEMBL138039 | — | — | 1 | 6.30 |
| CHEMBL343788 | — | — | 1 | 5.52 |
| CHEMBL335373 | — | — | 1 | 5.52 |
| CHEMBL337535 | — | — | 1 | 5.52 |
| CHEMBL335822 | — | — | 1 | 5.46 |
| CHEMBL3350557 | — | — | 1 | 5.46 |
| CHEMBL343990 | — | — | 1 | 5.46 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.40 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 5.40 |
| CHEMBL435422 | — | — | 1 | 5.16 |
| CHEMBL422107 | — | — | 1 | 5.05 |
| CHEMBL142141 | — | — | 1 | - |
| CHEMBL139266 | — | — | 1 | - |
| CHEMBL335122 | — | — | 1 | - |
| CHEMBL140891 | — | — | 1 | - |
| CHEMBL139517 | — | — | 1 | - |
| CHEMBL138041 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138757 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL138203 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL137842 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL370100 | REBECCAMYCIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL127277 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL137907 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL138039 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL343788 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL335373 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL337535 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL335822 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL3350557 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL343990 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL435422 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL422107 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL142141 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139266 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL335122 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL140891 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL139517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL138041 | — | IC50 | > | 10000.0 | nM | - |