Assay Detail
Binding
CHEMBL873883
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Inhibitory activity against Urokinase-type plasminogen activator
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of novel inhibitors of urokinase via NMR-based screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.26 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124692 | — | — | 1 | 6.30 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 5.16 |
| CHEMBL124632 | — | — | 1 | 5.16 |
| CHEMBL126589 | — | — | 1 | 5.00 |
| CHEMBL14047 | PHENYLGUANIDINE | — | 1 | 4.70 |
| CHEMBL305513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124692 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL945 | AMILORIDE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL124632 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL126589 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL14047 | PHENYLGUANIDINE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL305513 | — | IC50 | = | 200000.0 | nM | - |