Assay Detail
Binding
CHEMBL873990
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In Vitro inhibition of Thymidine Monophosphatase Kinase of Mycobacterium tuberculosis (TMPKm)
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 4.61 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | — | 1 | 5.00 |
| CHEMBL1161004 | — | — | 1 | 4.98 |
| CHEMBL1160994 | — | — | 1 | 4.92 |
| CHEMBL1160993 | — | — | 1 | 4.82 |
| CHEMBL52609 | DOXRIBTIMINE | 2.0 | 1 | 4.57 |
| CHEMBL1160596 | — | — | 1 | 4.57 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 4.55 |
| CHEMBL1161003 | — | — | 1 | 4.54 |
| CHEMBL340604 | — | — | 1 | 4.40 |
| CHEMBL124260 | — | — | 1 | 4.39 |
| CHEMBL127523 | — | — | 1 | 4.35 |
| CHEMBL341264 | — | — | 1 | 4.24 |
| CHEMBL124814 | — | — | 1 | - |
| CHEMBL124682 | — | — | 1 | - |
| CHEMBL1161002 | — | — | 1 | - |
| CHEMBL1160597 | — | — | 1 | - |
| CHEMBL1161001 | — | — | 1 | - |
| CHEMBL123912 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257695 | AZIDOTHYMIDINE MONOPHOSPHATE | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1161004 | — | Ki | = | 10500.0 | nM | 4.98 |
| CHEMBL1160994 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL1160993 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL52609 | DOXRIBTIMINE | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL1160596 | — | Ki | = | 27000.0 | nM | 4.57 |
| CHEMBL129 | ZIDOVUDINE | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL1161003 | — | Ki | = | 29000.0 | nM | 4.54 |
| CHEMBL340604 | — | Ki | = | 40000.0 | nM | 4.40 |
| CHEMBL124260 | — | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL127523 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL341264 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL124814 | — | Ki | = | 156000.0 | nM | - |
| CHEMBL124682 | — | Ki | = | 393000.0 | nM | - |
| CHEMBL1161002 | — | Ki | = | 116000.0 | nM | - |
| CHEMBL1160597 | — | Ki | = | 235000.0 | nM | - |
| CHEMBL1161001 | — | Ki | = | 315000.0 | nM | - |
| CHEMBL123912 | — | Ki | = | 770000.0 | nM | - |