Assay Detail
Functional
CHEMBL874051
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Concentration necessary for 50% inhibition of depolarization induced by 5 uM NMDA in mouse cortical wedge preparation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4- oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a]quinoxaline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.39 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 5.33 |
| CHEMBL267276 | TQX-173 | — | 1 | 4.34 |
| CHEMBL328935 | — | — | 1 | 4.30 |
| CHEMBL91115 | — | — | 1 | 4.30 |
| CHEMBL90722 | — | — | 1 | 4.28 |
| CHEMBL90242 | — | — | 1 | 4.22 |
| CHEMBL91677 | — | — | 1 | 4.22 |
| CHEMBL328272 | — | — | 1 | 4.10 |
| CHEMBL93076 | — | — | 1 | - |
| CHEMBL222519 | NBQX | — | 1 | - |
| CHEMBL327894 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL267276 | TQX-173 | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL328935 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL91115 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL90722 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL90242 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL91677 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL328272 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL93076 | — | IC50 | - | nM | - | |
| CHEMBL222519 | NBQX | IC50 | - | nM | - | |
| CHEMBL327894 | — | IC50 | = | 150000.0 | nM | - |