Assay Detail
Binding
CHEMBL874096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-phorbol 12,13-dibutyrate (PDBu) binding to human recombinant protein kinase C gamma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Rational design, synthesis, and biological evaluation of rigid pyrrolidone analogues as potential inhibitors of prostate cancer cell growth.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.08 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | 2.0 | 1 | 8.31 |
| CHEMBL6453 | — | — | 1 | 7.37 |
| CHEMBL368720 | — | — | 1 | 6.68 |
| CHEMBL440201 | — | — | 1 | 6.55 |
| CHEMBL173348 | — | — | 1 | 6.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL279115 | PHORBOL MYRISTATE ACETATE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL6453 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL368720 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL440201 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL173348 | — | Ki | = | 327.0 | nM | 6.49 |