Assay Detail
Binding
CHEMBL874110
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Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inhibition constant was determined after preincubating the enzyme and inhibitor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Inhibition of aminopeptidases by amastatin and bestatin derivatives. Effect of inhibitor structure on slow-binding processes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.77 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28650 | AMASTATIN | — | 1 | 7.70 |
| CHEMBL3143143 | — | — | 1 | 6.75 |
| CHEMBL134414 | — | — | 1 | 6.03 |
| CHEMBL1689155 | — | — | 1 | 4.93 |
| CHEMBL2370765 | — | — | 1 | 4.60 |
| CHEMBL2370764 | — | — | 1 | 4.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28650 | AMASTATIN | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3143143 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL134414 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL1689155 | — | Ki | = | 11760.0 | nM | 4.93 |
| CHEMBL2370765 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL2370764 | — | Ki | = | 26000.0 | nM | 4.58 |