Compound Detail
CHEMBL1689155
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Basic Information
| ChEMBL ID | CHEMBL1689155 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GPOZZLLZFGFHTR-VWYCJHECSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
274.4
MW (Da)
0.34
ALogP
4
HBA
4
HBD
112.7
PSA (Ų)
0.51
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cytosol aminopeptidase CHEMBL3965 | Ki | 6.92 | 6.92 | 120.0 | 1 |
| Aminopeptidase N CHEMBL2590 | Ki | 4.93 | 4.93 | 11760.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cytosol aminopeptidase | Ki | = | 120.0 | nM | 6.92 | Compound was evaluated for the inhibition of Leucine aminopeptidase and the inhi... | 6142952 |
| Aminopeptidase N | Ki | = | 11760.0 | nM | 4.93 | Compound was evaluated for the inhibition of Aminopeptidase M (AP-M) and the inh... | 6142952 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6142952 | 10.1021/jm00370a001 | Cytosol aminopeptidase | 1 |
| 6142952 | 10.1021/jm00370a001 | Aminopeptidase N | 1 |
| 21366301 | 10.1021/jm101227t | Aminopeptidase N | 1 |
| 21366301 | 10.1021/jm101227t | Plasmodium falciparum | 1 |
| 850237 | 10.1021/jm00214a010 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine