Assay Detail
Binding
CHEMBL874168
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inhibitory concentration against Melatonin receptor
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Coturnix |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Melatonin receptor ligands: synthesis of new melatonin derivatives and comprehensive comparative molecular field analysis (CoMFA) study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.75 | 9.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127337 | — | — | 1 | 9.18 |
| CHEMBL45 | MELATONIN | 4.0 | 1 | 8.66 |
| CHEMBL123900 | — | — | 1 | 7.89 |
| CHEMBL127134 | — | — | 1 | 7.63 |
| CHEMBL33700 | — | — | 1 | 7.59 |
| CHEMBL33800 | — | — | 1 | 7.47 |
| CHEMBL288562 | — | — | 1 | 6.90 |
| CHEMBL284521 | — | — | 1 | 6.53 |
| CHEMBL285477 | — | — | 1 | 6.31 |
| CHEMBL284158 | — | — | 1 | 6.14 |
| CHEMBL286814 | — | — | 1 | 6.11 |
| CHEMBL126809 | — | — | 1 | 5.99 |
| CHEMBL34327 | — | — | 1 | 5.96 |
| CHEMBL33869 | — | — | 1 | 5.83 |
| CHEMBL30930 | — | — | 1 | 5.61 |
| CHEMBL283600 | — | — | 1 | 5.58 |
| CHEMBL33099 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127337 | — | IC50 | = | 0.654 | nM | 9.18 |
| CHEMBL45 | MELATONIN | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL123900 | — | IC50 | = | 12.8 | nM | 7.89 |
| CHEMBL127134 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL33700 | — | IC50 | = | 25.5 | nM | 7.59 |
| CHEMBL33800 | — | IC50 | = | 33.6 | nM | 7.47 |
| CHEMBL288562 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL284521 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL285477 | — | IC50 | = | 491.0 | nM | 6.31 |
| CHEMBL284158 | — | IC50 | = | 719.0 | nM | 6.14 |
| CHEMBL286814 | — | IC50 | = | 772.0 | nM | 6.11 |
| CHEMBL126809 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL34327 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL33869 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL30930 | — | IC50 | = | 2460.0 | nM | 5.61 |
| CHEMBL283600 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL33099 | — | IC50 | = | 4800.0 | nM | 5.32 |