Assay Detail
Binding
CHEMBL874235
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Inhibition of rabbit lung angiotensin I converting enzyme (ACE) using hippuryl-histidyl-leucine as substrate
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Angiotensin-converting enzyme (CHEMBL4074) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
(Phosphinyloxy)acyl amino acid inhibitors of angiotensin converting enzyme. 2. Terminal amino acid analogues of (S)-1-[6-amino-2 [[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.61 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284843 | — | — | 1 | 9.00 |
| CHEMBL34650 | — | — | 1 | 8.82 |
| CHEMBL431707 | — | — | 1 | 8.59 |
| CHEMBL34832 | — | — | 1 | 8.52 |
| CHEMBL35309 | — | — | 1 | 8.46 |
| CHEMBL284734 | — | — | 1 | 8.36 |
| CHEMBL289022 | — | — | 1 | 8.03 |
| CHEMBL433442 | — | — | 1 | 8.01 |
| CHEMBL286339 | — | — | 1 | 7.96 |
| CHEMBL445561 | — | — | 1 | 7.80 |
| CHEMBL285935 | — | — | 1 | 7.66 |
| CHEMBL35561 | — | — | 1 | 7.62 |
| CHEMBL35419 | — | — | 1 | 7.60 |
| CHEMBL35815 | — | — | 1 | 7.58 |
| CHEMBL286111 | — | — | 1 | 7.55 |
| CHEMBL287518 | — | — | 1 | 7.51 |
| CHEMBL35682 | — | — | 1 | 7.46 |
| CHEMBL36503 | CERONAPRIL | 2.0 | 1 | 7.44 |
| CHEMBL35656 | — | — | 1 | 7.41 |
| CHEMBL430918 | — | — | 1 | 7.37 |
| CHEMBL34821 | — | — | 1 | 7.09 |
| CHEMBL284135 | — | — | 1 | 7.04 |
| CHEMBL33025 | — | — | 1 | 6.85 |
| CHEMBL264758 | — | — | 1 | 6.84 |
| CHEMBL285939 | — | — | 1 | 6.80 |
| CHEMBL286659 | — | — | 1 | 6.77 |
| CHEMBL284272 | — | — | 1 | 6.57 |
| CHEMBL35310 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284843 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL34650 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL431707 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL34832 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL35309 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL284734 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL289022 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL433442 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL286339 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL445561 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL285935 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL35561 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL35419 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL35815 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL286111 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL287518 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL35682 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL36503 | CERONAPRIL | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL35656 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL430918 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL34821 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL284135 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL33025 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL264758 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL285939 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL286659 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL284272 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL35310 | — | IC50 | = | 320.0 | nM | 6.50 |