Compound Detail
CHEMBL36503
CERONAPRIL 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL36503 |
| Name | CERONAPRIL |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IFYLTXNCFVRALQ-OALUTQOASA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
3
Known Names
Molecular Properties
440.5
MW (Da)
2.78
ALogP
5
HBA
3
HBD
130.2
PSA (Ų)
0.32
QED
0
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Activity Summary
IC50 3 meas. best 7.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Angiotensin-converting enzyme CHEMBL1808 | IC50 | 7.44 | 7.44 | 36.3 | 1 |
| Angiotensin-converting enzyme CHEMBL4074 | IC50 | 7.44 | 7.44 | 36.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | IC50 | = | 36.0 | nM | 7.44 | Inhibition of rabbit lung angiotensin I converting enzyme (ACE) using hippuryl-h... | 2329568 |
| Angiotensin-converting enzyme | IC50 | = | 36.0 | nM | 7.44 | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippu... | 3336020 |
| Angiotensin-converting enzyme | IC50 | = | 36.31 | nM | 7.44 | Inhibitory activity against angiotensin converting enzyme (ACE) | 8360884 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 2329568 | 10.1021/jm00167a028 | Angiotensin-converting enzyme | 3 |
| 3336020 | 10.1021/jm00396a033 | Rattus norvegicus | 3 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 3336020 | 10.1021/jm00396a033 | Angiotensin-converting enzyme | 1 |
| 8360884 | 10.1021/jm00068a017 | Angiotensin-converting enzyme | 1 |
Data from ChEMBL 36 via Core Engine