Assay Detail
ADMET
CHEMBL874551
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Inhibition of cytochrome P450 2D6 was determined using MAMC (7-methoxy-4-aminomethyl-coumarin) as substrate
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylacetamide kappa opioid receptor agonists with reduced cytochrome P450 2D6 inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.14 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192677 | — | — | 1 | 7.75 |
| CHEMBL38576 | ICI-199,441 | — | 1 | 7.58 |
| CHEMBL539685 | — | — | 1 | 7.46 |
| CHEMBL94734 | — | — | 1 | 7.34 |
| CHEMBL192734 | — | — | 1 | 6.97 |
| CHEMBL364907 | — | — | 1 | 6.53 |
| CHEMBL189257 | — | — | 1 | 6.49 |
| CHEMBL192964 | — | — | 1 | 6.22 |
| CHEMBL363718 | — | — | 1 | 5.98 |
| CHEMBL359557 | — | — | 1 | 5.96 |
| CHEMBL192520 | — | — | 1 | 5.91 |
| CHEMBL190030 | — | — | 1 | 5.74 |
| CHEMBL190600 | — | — | 1 | 5.36 |
| CHEMBL370538 | — | — | 1 | 5.32 |
| CHEMBL191987 | — | — | 1 | 5.26 |
| CHEMBL192998 | — | — | 1 | 5.25 |
| CHEMBL190353 | — | — | 1 | 5.24 |
| CHEMBL189643 | — | — | 1 | 5.24 |
| CHEMBL362741 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192677 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL38576 | ICI-199,441 | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL539685 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL94734 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL192734 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL364907 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL189257 | — | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL192964 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL363718 | — | IC50 | = | 1037.0 | nM | 5.98 |
| CHEMBL359557 | — | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL192520 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL190030 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL190600 | — | IC50 | = | 4337.0 | nM | 5.36 |
| CHEMBL370538 | — | IC50 | = | 4776.0 | nM | 5.32 |
| CHEMBL191987 | — | IC50 | = | 5526.0 | nM | 5.26 |
| CHEMBL192998 | — | IC50 | = | 5653.0 | nM | 5.25 |
| CHEMBL190353 | — | IC50 | = | 5792.0 | nM | 5.24 |
| CHEMBL189643 | — | IC50 | = | 5702.0 | nM | 5.24 |
| CHEMBL362741 | — | IC50 | = | 7888.0 | nM | 5.10 |