Assay Detail
Binding
CHEMBL874633
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Binding affinity was measured in cloned Opioid receptor mu 1 expressed in CHO cells using [3H]- DAMGO as radioligand.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of N,N-dialkyl enkephalin-based affinity labels for delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.02 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL15032 | — | — | 1 | 5.80 |
| CHEMBL2112657 | — | — | 1 | 5.72 |
| CHEMBL2112658 | — | — | 1 | 5.64 |
| CHEMBL128911 | — | — | 1 | 5.04 |
| CHEMBL47545 | — | — | 1 | 4.72 |
| CHEMBL2370648 | — | — | 1 | 4.72 |
| CHEMBL2370650 | — | — | 1 | 4.48 |
| CHEMBL2112659 | — | — | 1 | 4.06 |
| CHEMBL2370649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL15032 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2112657 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2112658 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL128911 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL47545 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL2370648 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2370650 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL2112659 | — | IC50 | = | 87700.0 | nM | 4.06 |
| CHEMBL2370649 | — | IC50 | > | 10000.0 | nM | - |