Assay Detail
Functional
CHEMBL874932
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of maximum response on CHO-K1 cells expressing human Follicle stimulating hormone receptor
20
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CHO-K1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Follicle-stimulating hormone receptor (CHEMBL2024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of substituted 6-amino-4-phenyltetrahydroquinoline derivatives: potent antagonists for the follicle-stimulating hormone receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.22 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192135 | — | — | 2 | 8.40 |
| CHEMBL360981 | — | — | 1 | 8.30 |
| CHEMBL436481 | — | — | 1 | 8.30 |
| CHEMBL361847 | — | — | 1 | 8.15 |
| CHEMBL365545 | — | — | 1 | 8.05 |
| CHEMBL195469 | — | — | 1 | 7.60 |
| CHEMBL361167 | — | — | 1 | 7.57 |
| CHEMBL192868 | — | — | 1 | 7.52 |
| CHEMBL178980 | — | — | 1 | 7.51 |
| CHEMBL195347 | — | — | 1 | 7.30 |
| CHEMBL192334 | — | — | 1 | 7.27 |
| CHEMBL179505 | — | — | 1 | 7.12 |
| CHEMBL372649 | — | — | 1 | 6.78 |
| CHEMBL426824 | — | — | 1 | 6.77 |
| CHEMBL363164 | — | — | 1 | 6.62 |
| CHEMBL372506 | — | — | 1 | 6.24 |
| CHEMBL194996 | — | — | 1 | 6.03 |
| CHEMBL195321 | — | — | 1 | 5.73 |
| CHEMBL371595 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192135 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL360981 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL436481 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL361847 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL365545 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL195469 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL361167 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL192135 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL192868 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL178980 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL195347 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL192334 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL179505 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL372649 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL426824 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL363164 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL372506 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL194996 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL195321 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL371595 | — | IC50 | = | 2800.0 | nM | 5.55 |