Assay Detail
Binding
CHEMBL875197
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Inhibitory activity against coagulation factor II (thrombin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 5.38 | 5.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182746 | — | — | 1 | 5.56 |
| CHEMBL440755 | — | — | 1 | 5.50 |
| CHEMBL180695 | — | — | 1 | 5.08 |
| CHEMBL366134 | — | — | 1 | - |
| CHEMBL182763 | — | — | 1 | - |
| CHEMBL185556 | — | — | 1 | - |
| CHEMBL182975 | — | — | 1 | - |
| CHEMBL183426 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182746 | — | Ki | = | 2760.0 | nM | 5.56 |
| CHEMBL440755 | — | Ki | = | 3160.0 | nM | 5.50 |
| CHEMBL180695 | — | Ki | = | 8220.0 | nM | 5.08 |
| CHEMBL366134 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL182763 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL185556 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL182975 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL183426 | — | Ki | > | 10000.0 | nM | - |