Assay Detail
Binding
CHEMBL875217
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In vitro inhibitory activity against cloned human M2 muscarinic receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Himbacine analogs as muscarinic receptor antagonists--effects of tether and heterocyclic variations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.35 | 8.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355854 | — | — | 1 | 8.37 |
| CHEMBL277642 | HIMBACINE | — | 1 | 8.35 |
| CHEMBL183903 | — | — | 1 | 7.91 |
| CHEMBL182761 | — | — | 1 | 7.88 |
| CHEMBL427145 | — | — | 1 | 7.80 |
| CHEMBL184843 | — | — | 1 | 7.37 |
| CHEMBL181447 | — | — | 1 | 7.17 |
| CHEMBL363895 | — | — | 1 | 6.75 |
| CHEMBL360988 | — | — | 1 | 6.69 |
| CHEMBL183331 | — | — | 1 | 6.35 |
| CHEMBL362864 | — | — | 1 | 6.24 |
| CHEMBL433566 | — | — | 1 | - |
| CHEMBL360904 | — | — | 1 | - |
| CHEMBL182777 | — | — | 1 | - |
| CHEMBL359847 | — | — | 1 | - |
| CHEMBL360154 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355854 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL277642 | HIMBACINE | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL183903 | — | Ki | = | 12.2 | nM | 7.91 |
| CHEMBL182761 | — | Ki | = | 13.3 | nM | 7.88 |
| CHEMBL427145 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL184843 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL181447 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL363895 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL360988 | — | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL183331 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL362864 | — | Ki | = | 571.0 | nM | 6.24 |
| CHEMBL433566 | — | Ki | > | 1400.0 | nM | - |
| CHEMBL360904 | — | Ki | > | 1400.0 | nM | - |
| CHEMBL182777 | — | Ki | > | 1400.0 | nM | - |
| CHEMBL359847 | — | Ki | > | 1400.0 | nM | - |
| CHEMBL360154 | — | Ki | > | 1400.0 | nM | - |