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Compound Detail

CHEMBL181447

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C[C@@H]1OC(=O)[C@H]2C=C3CCCC[C@@H]3/C(=C/CC3CCC(C)(C)N3C)[C@@H]12

Basic Information

ChEMBL ID CHEMBL181447
Phase Preclinical
Structure Type MOL
InChI Key BFWLLXLCNDBKTL-BXJHODBTSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

343.5
MW (Da)
4.48
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H33NO2
MW 343.51
Aromatic Rings 0
Heavy Atoms 25
NP-Likeness 1.33

Activity Summary

Ki 2 meas. best 7.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 7.17 7.17 68.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 6.75 6.75 177.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15225708 10.1016/j.bmcl.2004.05.047 Muscarinic acetylcholine receptor M2 1
15225708 10.1016/j.bmcl.2004.05.047 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine