Assay Detail
Binding
CHEMBL875910
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Binding affinity for 5-HT 2A in rat stomach fundus
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Stomach |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, selective tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.81 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96485 | — | — | 1 | 8.57 |
| CHEMBL319009 | — | — | 1 | 8.53 |
| CHEMBL1202891 | — | — | 1 | 8.45 |
| CHEMBL96480 | — | — | 1 | 8.33 |
| CHEMBL96782 | — | — | 1 | 8.06 |
| CHEMBL94644 | — | — | 1 | 7.78 |
| CHEMBL95121 | — | — | 1 | 7.71 |
| CHEMBL96559 | — | — | 1 | 7.65 |
| CHEMBL323330 | — | — | 1 | 7.18 |
| CHEMBL15245 | YOHIMBINE | 3.0 | 1 | 5.79 |
| CHEMBL85194 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96485 | — | Ki | = | 2.692 | nM | 8.57 |
| CHEMBL319009 | — | Ki | = | 2.951 | nM | 8.53 |
| CHEMBL1202891 | — | Ki | = | 3.548 | nM | 8.45 |
| CHEMBL96480 | — | Ki | = | 4.677 | nM | 8.33 |
| CHEMBL96782 | — | Ki | = | 8.71 | nM | 8.06 |
| CHEMBL94644 | — | Ki | = | 16.6 | nM | 7.78 |
| CHEMBL95121 | — | Ki | = | 19.5 | nM | 7.71 |
| CHEMBL96559 | — | Ki | = | 22.39 | nM | 7.65 |
| CHEMBL323330 | — | Ki | = | 66.07 | nM | 7.18 |
| CHEMBL15245 | YOHIMBINE | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL85194 | — | Ki | > | 6309.57 | nM | - |