Assay Detail
Functional
CHEMBL876002
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of compound on nitric oxide (NO) production in lipopolysaccharide activated mouse peritoneal macrophages
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of 1'S-1'-acetoxychavicol acetate for inhibitory effect on NO production in lipopolysaccharide-activated mouse peritoneal macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 4.79 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL323727 | 1'-ACETOXYCHAVICOL ACETATE | — | 1 | 5.64 |
| CHEMBL360018 | — | — | 1 | 5.50 |
| CHEMBL359887 | — | — | 1 | 5.31 |
| CHEMBL105278 | GUANIDINOETHYLDISULFIDE | — | 1 | 5.13 |
| CHEMBL414656 | — | — | 1 | 5.09 |
| CHEMBL433561 | — | — | 1 | 5.04 |
| CHEMBL181165 | — | — | 1 | 5.00 |
| CHEMBL111484 | — | — | 1 | 4.96 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 4.82 |
| CHEMBL111134 | HYDROXYCHAVICOL | — | 1 | 4.82 |
| CHEMBL444328 | — | — | 1 | 4.72 |
| CHEMBL431836 | p-HYDROXYCINNAMALDEHYDE | — | 1 | 4.70 |
| CHEMBL179859 | — | — | 1 | 4.52 |
| CHEMBL181511 | — | — | 1 | 4.33 |
| CHEMBL180795 | — | — | 1 | 4.23 |
| CHEMBL108937 | — | — | 1 | 4.19 |
| CHEMBL111715 | — | — | 1 | 4.14 |
| CHEMBL180091 | — | — | 1 | 4.00 |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL109034 | — | — | 1 | - |
| CHEMBL52564 | O-COUMARIC ACID | — | 1 | - |
| CHEMBL98521 | — | — | 1 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | — | 1 | - |
| CHEMBL332148 | — | — | 1 | - |
| CHEMBL179846 | — | — | 1 | - |
| CHEMBL14253 | ACETONE | -1.0 | 1 | - |
| CHEMBL108861 | METHYLEUGENOL | — | 1 | - |
| CHEMBL181042 | — | — | 1 | - |
| CHEMBL109341 | SINAPINATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL323727 | 1'-ACETOXYCHAVICOL ACETATE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL360018 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL359887 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL105278 | GUANIDINOETHYLDISULFIDE | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL414656 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL433561 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL181165 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL111484 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL111134 | HYDROXYCHAVICOL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL444328 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL431836 | p-HYDROXYCINNAMALDEHYDE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL179859 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL181511 | — | IC50 | = | 47000.0 | nM | 4.33 |
| CHEMBL180795 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL108937 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL111715 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL180091 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL179994 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL345759 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL42710 | EUGENOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL179783 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108862 | CHAVICOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL181178 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL180638 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL181890 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL180737 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL179832 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL181994 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL181777 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL107839 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325573 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL322787 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109341 | SINAPINATE | IC50 | > | 100000.0 | nM | - |
| CHEMBL181042 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL108861 | METHYLEUGENOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL14253 | ACETONE | IC50 | > | 7.3 | ug.mL-1 | - |
| CHEMBL179846 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332148 | — | IC50 | > | 57000.0 | nM | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL98521 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL52564 | O-COUMARIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL109034 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL27246 | CINNAMIC ACID | IC50 | > | 100000.0 | nM | - |