Assay Detail
Binding
CHEMBL876356
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Binding affinity for human beta-2 adrenergic receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Long-chain formoterol analogues: an investigation into the effect of increasing amino-substituent chain length on the beta2-adrenoceptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.21 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | 4.0 | 1 | 9.00 |
| CHEMBL1256786 | FORMOTEROL | 4.0 | 1 | 8.59 |
| CHEMBL183948 | — | — | 1 | 8.48 |
| CHEMBL363329 | — | — | 1 | 8.23 |
| CHEMBL363260 | — | — | 1 | 8.11 |
| CHEMBL440561 | — | — | 1 | 8.07 |
| CHEMBL185052 | — | — | 1 | 8.04 |
| CHEMBL184538 | — | — | 1 | 7.94 |
| CHEMBL185262 | — | — | 1 | 7.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1263 | SALMETEROL | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL1256786 | FORMOTEROL | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL183948 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL363329 | — | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL363260 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL440561 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL185052 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL184538 | — | Ki | = | 11.6 | nM | 7.94 |
| CHEMBL185262 | — | Ki | = | 35.4 | nM | 7.45 |