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Assay Detail

CHEMBL876700

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Binding
Compound is evaluated for its ability to inhibit [3H]LTD4 binding to Cysteinyl leukotriene D4 receptor in guinea pig lung membranes
ChEMBL ↗
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Cavia porcellus
Tissue Lung
Subcellular Membrane
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cysteinyl leukotriene receptor (CHEMBL2094254) ↗
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists.
Perchonock CD, Uzinskas I, McCarthy ME, Erhard KF, Gleason JG, Wasserman MA, Muccitelli RM, DeVan JF, Tucker SS, Vickery LM.
J Med Chem (1986) 29 : 1442 -1452
PubMed 3016267 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 46 6.03 7.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL35611 — — 1 7.11
CHEMBL285073 — — 1 6.85
CHEMBL287354 — — 1 6.83
CHEMBL286074 — — 1 6.81
CHEMBL33712 — — 1 6.73
CHEMBL15489 — — 1 6.61
CHEMBL32489 — — 1 6.54
CHEMBL35497 — — 1 6.52
CHEMBL35892 — — 1 6.40
CHEMBL33764 — — 1 6.37
CHEMBL418049 — — 1 6.37
CHEMBL15367 — — 1 6.35
CHEMBL33020 — — 1 6.32
CHEMBL32376 — — 1 6.31
CHEMBL34944 — — 1 6.28
CHEMBL32269 — — 1 6.24
CHEMBL33713 — — 1 6.21
CHEMBL35070 — — 1 6.21
CHEMBL36176 — — 1 6.19
CHEMBL36523 — — 1 6.07
CHEMBL36524 — — 1 6.03
CHEMBL35342 — — 1 6.00
CHEMBL35861 — — 1 6.00
CHEMBL32607 — — 1 5.93
CHEMBL284043 — — 1 5.90
CHEMBL2114390 — — 1 5.86
CHEMBL430934 — — 1 5.71
CHEMBL267976 FPL-55712 SODIUM SALT — 1 5.70
CHEMBL284722 — — 1 5.68
CHEMBL32435 — — 1 5.63

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL35611 — Ki = 78.0 nM 7.11
CHEMBL285073 — Ki = 141.0 nM 6.85
CHEMBL287354 — Ki = 147.0 nM 6.83
CHEMBL286074 — Ki = 156.0 nM 6.81
CHEMBL33712 — Ki = 187.0 nM 6.73
CHEMBL15489 — Ki = 245.0 nM 6.61
CHEMBL32489 — Ki = 287.0 nM 6.54
CHEMBL35497 — Ki = 303.0 nM 6.52
CHEMBL35892 — Ki = 401.0 nM 6.40
CHEMBL33764 — Ki = 423.0 nM 6.37
CHEMBL418049 — Ki = 430.0 nM 6.37
CHEMBL15367 — Ki = 445.0 nM 6.35
CHEMBL33020 — Ki = 476.0 nM 6.32
CHEMBL32376 — Ki = 491.0 nM 6.31
CHEMBL34944 — Ki = 530.0 nM 6.28
CHEMBL32269 — Ki = 579.0 nM 6.24
CHEMBL33713 — Ki = 624.0 nM 6.21
CHEMBL35070 — Ki = 624.0 nM 6.21
CHEMBL36176 — Ki = 646.0 nM 6.19
CHEMBL36523 — Ki = 846.0 nM 6.07
CHEMBL36524 — Ki = 934.0 nM 6.03
CHEMBL35342 — Ki = 1009.0 nM 6.00
CHEMBL35861 — Ki = 1002.0 nM 6.00
CHEMBL32607 — Ki = 1180.0 nM 5.93
CHEMBL284043 — Ki = 1246.0 nM 5.90
CHEMBL2114390 — Ki = 1380.0 nM 5.86
CHEMBL430934 — Ki = 1958.0 nM 5.71
CHEMBL267976 FPL-55712 SODIUM SALT Ki = 2007.0 nM 5.70
CHEMBL284722 — Ki = 2092.0 nM 5.68
CHEMBL32435 — Ki = 2337.0 nM 5.63
CHEMBL418042 — Ki = 2515.0 nM 5.60
CHEMBL34890 — Ki = 3149.0 nM 5.50
CHEMBL33646 — Ki = 3672.0 nM 5.43
CHEMBL35667 — Ki = 4094.0 nM 5.39
CHEMBL33932 — Ki = 4228.0 nM 5.37
CHEMBL33254 — Ki = 5674.0 nM 5.25
CHEMBL33076 — Ki = 7565.0 nM 5.12
CHEMBL36013 — Ki = 11526.0 nM 4.94
CHEMBL32434 — Ki = 17578.0 nM 4.75
CHEMBL35010 — Ki > 20000.0 nM -
CHEMBL32558 — Ki > 20000.0 nM -
CHEMBL36344 — Ki > 20000.0 nM -
CHEMBL35887 — Ki > 20000.0 nM -
CHEMBL416949 — Ki > 20000.0 nM -
CHEMBL32638 — Ki > 20000.0 nM -
CHEMBL32168 — Ki > 20000.0 nM -