Assay Detail
Binding
CHEMBL877452
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for serotonin transporter expressed in LCK PK1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LCK PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-(2-(dimethylaminomethyl)phenoxy)-5-iodophenylamine: an improved serotonin transporter imaging agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 9.05 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23034 | — | — | 1 | 11.00 |
| CHEMBL114275 | — | — | 1 | 10.05 |
| CHEMBL183470 | — | — | 1 | 9.92 |
| CHEMBL186962 | — | — | 1 | 9.43 |
| CHEMBL106939 | DASB | 1.0 | 1 | 8.96 |
| CHEMBL186056 | — | — | 1 | 7.31 |
| CHEMBL295467 | NISOXETINE | 2.0 | 1 | 6.69 |
| CHEMBL361259 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23034 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL114275 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL183470 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL186962 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL106939 | DASB | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL186056 | — | Ki | = | 48.6 | nM | 7.31 |
| CHEMBL295467 | NISOXETINE | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL361259 | — | Ki | = | 0.009 | nM | - |