Assay Detail
Binding
CHEMBL878289
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In vitro binding affinity towards Dopamine receptor D2
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Orally active oxime derivatives of the dopaminergic prodrug 6-(N,N-di-n-propylamino)-3,4,5,6,7,8-hexahydro-2H-naphthalen-1-one. Synthesis and pharmacological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11845 | — | — | 1 | 8.52 |
| CHEMBL132575 | — | — | 1 | 5.65 |
| CHEMBL130398 | — | — | 1 | 5.64 |
| CHEMBL132626 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11845 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL132575 | — | Ki | = | 2234.0 | nM | 5.65 |
| CHEMBL130398 | — | Ki | = | 2295.0 | nM | 5.64 |
| CHEMBL132626 | — | Ki | > | 10000.0 | nM | - |